Premature Ejaculation Cures

Core Evid. 2012; 7: 1-14
McCarty E, Dinsmore W

Premature ejaculation (PE) is a major issue in male sexual health. The global prevalence of PE is estimated to be between 20% and 40%, making it the most common sexual dysfunction in men. PE causes distress and reduced quality of life for patients and has a negative impact on interpersonal relationships. Historically, it has been treated with cognitive therapy, behavioral methods, and off-label use of selective serotonin reuptake inhibitors usually used to treat depression and other psychological disorders. Dapoxetine is a selective serotonin reuptake inhibitor specifically designed to treat PE. This paper reviews the current evidence for use of dapoxetine in the treatment of PE in adult men. There is substantial evidence that dapoxetine 30 mg or 60 mg taken “on-demand” results in a significant increase in intravaginal ejaculatory latency time when compared with placebo. Patient-reported outcomes are clearly improved relative to placebo following dapoxetine therapy, indicating greater control over ejaculation, more satisfaction with intercourse, less ejaculation-related distress, and, importantly, significantly reduced interpersonal difficulty. These data were supported by consistent reports of improvement in Clinical Global Impression of change in PE following treatment with dapoxetine. Further studies are needed to evaluate long-term efficacy and health economics. The unique pharmacology of dapoxetine makes it ideal for on-demand dosing, and the clinical evidence shows dapoxetine to be an efficacious and tolerable treatment for lifelong and acquired PE.

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J Obstet Gynaecol. 2012 Feb; 32(2): 180-4
Rodríguez MC, Chedraui P, Schwager G, Hidalgo L, Pérez-López FR

The present study aimed at assessing sexuality after hysterectomy using the Female Sexual Function Index (FSFI). A telephone survey was conducted among women 1 year after a hysterectomy for benign cause. The FSFI and a general questionnaire containing personal and partner sociodemographic data were applied. A total of 100 sexually active women participated. Bilateral oophorectomy was performed among 41%. Upon survey, 63% were on hormone therapy (HT) and 2% on psychotropic drugs. Regarding the partner (n = 100), 32% abused alcohol; 11% had erectile dysfunction; 67% premature ejaculation and 11% were unfaithful. Total FSFI score was 19.4 ± 3.6 (median 19.8) and for the domains: 3.2 ± 0.9 (desire); 3.2 ± 0.9 (arousal); 3.1 ± 0.6 (lubrication); 3.1 ± 0.7 (orgasm); 3.5 ± 1.1 (satisfaction) and 3.2 ± 1.2 (pain/dyspareunia). All women displayed sexual dysfunction (total FSFI score ≤ 26.55). A total of 53% presented FSFI scores equal to or below the calculated median for the series. Logistic regression determined that among women who had had a hysterectomy, male premature ejaculation was related to an overall poorer female sexual function (lower total FSFI scorings), whereas sometime oral contraceptive use decreased this risk. Age (female or male) and male sexual dysfunction were factors related to lower individual FSFI domain scores.

Read Full Article

J Obstet Gynaecol. 2012 Feb; 32(2): 180-4
Rodríguez MC, Chedraui P, Schwager G, Hidalgo L, Pérez-López FR

The present study aimed at assessing sexuality after hysterectomy using the Female Sexual Function Index (FSFI). A telephone survey was conducted among women 1 year after a hysterectomy for benign cause. The FSFI and a general questionnaire containing personal and partner sociodemographic data were applied. A total of 100 sexually active women participated. Bilateral oophorectomy was performed among 41%. Upon survey, 63% were on hormone therapy (HT) and 2% on psychotropic drugs. Regarding the partner (n = 100), 32% abused alcohol; 11% had erectile dysfunction; 67% premature ejaculation and 11% were unfaithful. Total FSFI score was 19.4 ± 3.6 (median 19.8) and for the domains: 3.2 ± 0.9 (desire); 3.2 ± 0.9 (arousal); 3.1 ± 0.6 (lubrication); 3.1 ± 0.7 (orgasm); 3.5 ± 1.1 (satisfaction) and 3.2 ± 1.2 (pain/dyspareunia). All women displayed sexual dysfunction (total FSFI score ≤ 26.55). A total of 53% presented FSFI scores equal to or below the calculated median for the series. Logistic regression determined that among women who had had a hysterectomy, male premature ejaculation was related to an overall poorer female sexual function (lower total FSFI scorings), whereas sometime oral contraceptive use decreased this risk. Age (female or male) and male sexual dysfunction were factors related to lower individual FSFI domain scores.

Read Full Article

J Obstet Gynaecol. 2012 Feb; 32(2): 180-4
Rodríguez MC, Chedraui P, Schwager G, Hidalgo L, Pérez-López FR

The present study aimed at assessing sexuality after hysterectomy using the Female Sexual Function Index (FSFI). A telephone survey was conducted among women 1 year after a hysterectomy for benign cause. The FSFI and a general questionnaire containing personal and partner sociodemographic data were applied. A total of 100 sexually active women participated. Bilateral oophorectomy was performed among 41%. Upon survey, 63% were on hormone therapy (HT) and 2% on psychotropic drugs. Regarding the partner (n = 100), 32% abused alcohol; 11% had erectile dysfunction; 67% premature ejaculation and 11% were unfaithful. Total FSFI score was 19.4 ± 3.6 (median 19.8) and for the domains: 3.2 ± 0.9 (desire); 3.2 ± 0.9 (arousal); 3.1 ± 0.6 (lubrication); 3.1 ± 0.7 (orgasm); 3.5 ± 1.1 (satisfaction) and 3.2 ± 1.2 (pain/dyspareunia). All women displayed sexual dysfunction (total FSFI score ≤ 26.55). A total of 53% presented FSFI scores equal to or below the calculated median for the series. Logistic regression determined that among women who had had a hysterectomy, male premature ejaculation was related to an overall poorer female sexual function (lower total FSFI scorings), whereas sometime oral contraceptive use decreased this risk. Age (female or male) and male sexual dysfunction were factors related to lower individual FSFI domain scores.

Read Full Article

J Obstet Gynaecol. 2012 Feb; 32(2): 180-4
Rodríguez MC, Chedraui P, Schwager G, Hidalgo L, Pérez-López FR

The present study aimed at assessing sexuality after hysterectomy using the Female Sexual Function Index (FSFI). A telephone survey was conducted among women 1 year after a hysterectomy for benign cause. The FSFI and a general questionnaire containing personal and partner sociodemographic data were applied. A total of 100 sexually active women participated. Bilateral oophorectomy was performed among 41%. Upon survey, 63% were on hormone therapy (HT) and 2% on psychotropic drugs. Regarding the partner (n = 100), 32% abused alcohol; 11% had erectile dysfunction; 67% premature ejaculation and 11% were unfaithful. Total FSFI score was 19.4 ± 3.6 (median 19.8) and for the domains: 3.2 ± 0.9 (desire); 3.2 ± 0.9 (arousal); 3.1 ± 0.6 (lubrication); 3.1 ± 0.7 (orgasm); 3.5 ± 1.1 (satisfaction) and 3.2 ± 1.2 (pain/dyspareunia). All women displayed sexual dysfunction (total FSFI score ≤ 26.55). A total of 53% presented FSFI scores equal to or below the calculated median for the series. Logistic regression determined that among women who had had a hysterectomy, male premature ejaculation was related to an overall poorer female sexual function (lower total FSFI scorings), whereas sometime oral contraceptive use decreased this risk. Age (female or male) and male sexual dysfunction were factors related to lower individual FSFI domain scores.

Read Full Article

J Obstet Gynaecol. 2012 Feb; 32(2): 180-4
Rodríguez MC, Chedraui P, Schwager G, Hidalgo L, Pérez-López FR

The present study aimed at assessing sexuality after hysterectomy using the Female Sexual Function Index (FSFI). A telephone survey was conducted among women 1 year after a hysterectomy for benign cause. The FSFI and a general questionnaire containing personal and partner sociodemographic data were applied. A total of 100 sexually active women participated. Bilateral oophorectomy was performed among 41%. Upon survey, 63% were on hormone therapy (HT) and 2% on psychotropic drugs. Regarding the partner (n = 100), 32% abused alcohol; 11% had erectile dysfunction; 67% premature ejaculation and 11% were unfaithful. Total FSFI score was 19.4 ± 3.6 (median 19.8) and for the domains: 3.2 ± 0.9 (desire); 3.2 ± 0.9 (arousal); 3.1 ± 0.6 (lubrication); 3.1 ± 0.7 (orgasm); 3.5 ± 1.1 (satisfaction) and 3.2 ± 1.2 (pain/dyspareunia). All women displayed sexual dysfunction (total FSFI score ≤ 26.55). A total of 53% presented FSFI scores equal to or below the calculated median for the series. Logistic regression determined that among women who had had a hysterectomy, male premature ejaculation was related to an overall poorer female sexual function (lower total FSFI scorings), whereas sometime oral contraceptive use decreased this risk. Age (female or male) and male sexual dysfunction were factors related to lower individual FSFI domain scores.

Read Full Article

J Obstet Gynaecol. 2012 Feb; 32(2): 180-4
Rodríguez MC, Chedraui P, Schwager G, Hidalgo L, Pérez-López FR

The present study aimed at assessing sexuality after hysterectomy using the Female Sexual Function Index (FSFI). A telephone survey was conducted among women 1 year after a hysterectomy for benign cause. The FSFI and a general questionnaire containing personal and partner sociodemographic data were applied. A total of 100 sexually active women participated. Bilateral oophorectomy was performed among 41%. Upon survey, 63% were on hormone therapy (HT) and 2% on psychotropic drugs. Regarding the partner (n = 100), 32% abused alcohol; 11% had erectile dysfunction; 67% premature ejaculation and 11% were unfaithful. Total FSFI score was 19.4 ± 3.6 (median 19.8) and for the domains: 3.2 ± 0.9 (desire); 3.2 ± 0.9 (arousal); 3.1 ± 0.6 (lubrication); 3.1 ± 0.7 (orgasm); 3.5 ± 1.1 (satisfaction) and 3.2 ± 1.2 (pain/dyspareunia). All women displayed sexual dysfunction (total FSFI score ≤ 26.55). A total of 53% presented FSFI scores equal to or below the calculated median for the series. Logistic regression determined that among women who had had a hysterectomy, male premature ejaculation was related to an overall poorer female sexual function (lower total FSFI scorings), whereas sometime oral contraceptive use decreased this risk. Age (female or male) and male sexual dysfunction were factors related to lower individual FSFI domain scores.

Read Full Article

J Obstet Gynaecol. 2012 Feb; 32(2): 180-4
Rodríguez MC, Chedraui P, Schwager G, Hidalgo L, Pérez-López FR

The present study aimed at assessing sexuality after hysterectomy using the Female Sexual Function Index (FSFI). A telephone survey was conducted among women 1 year after a hysterectomy for benign cause. The FSFI and a general questionnaire containing personal and partner sociodemographic data were applied. A total of 100 sexually active women participated. Bilateral oophorectomy was performed among 41%. Upon survey, 63% were on hormone therapy (HT) and 2% on psychotropic drugs. Regarding the partner (n = 100), 32% abused alcohol; 11% had erectile dysfunction; 67% premature ejaculation and 11% were unfaithful. Total FSFI score was 19.4 ± 3.6 (median 19.8) and for the domains: 3.2 ± 0.9 (desire); 3.2 ± 0.9 (arousal); 3.1 ± 0.6 (lubrication); 3.1 ± 0.7 (orgasm); 3.5 ± 1.1 (satisfaction) and 3.2 ± 1.2 (pain/dyspareunia). All women displayed sexual dysfunction (total FSFI score ≤ 26.55). A total of 53% presented FSFI scores equal to or below the calculated median for the series. Logistic regression determined that among women who had had a hysterectomy, male premature ejaculation was related to an overall poorer female sexual function (lower total FSFI scorings), whereas sometime oral contraceptive use decreased this risk. Age (female or male) and male sexual dysfunction were factors related to lower individual FSFI domain scores.

Read Full Article

J Obstet Gynaecol. 2012 Feb; 32(2): 180-4
Rodríguez MC, Chedraui P, Schwager G, Hidalgo L, Pérez-López FR

The present study aimed at assessing sexuality after hysterectomy using the Female Sexual Function Index (FSFI). A telephone survey was conducted among women 1 year after a hysterectomy for benign cause. The FSFI and a general questionnaire containing personal and partner sociodemographic data were applied. A total of 100 sexually active women participated. Bilateral oophorectomy was performed among 41%. Upon survey, 63% were on hormone therapy (HT) and 2% on psychotropic drugs. Regarding the partner (n = 100), 32% abused alcohol; 11% had erectile dysfunction; 67% premature ejaculation and 11% were unfaithful. Total FSFI score was 19.4 ± 3.6 (median 19.8) and for the domains: 3.2 ± 0.9 (desire); 3.2 ± 0.9 (arousal); 3.1 ± 0.6 (lubrication); 3.1 ± 0.7 (orgasm); 3.5 ± 1.1 (satisfaction) and 3.2 ± 1.2 (pain/dyspareunia). All women displayed sexual dysfunction (total FSFI score ≤ 26.55). A total of 53% presented FSFI scores equal to or below the calculated median for the series. Logistic regression determined that among women who had had a hysterectomy, male premature ejaculation was related to an overall poorer female sexual function (lower total FSFI scorings), whereas sometime oral contraceptive use decreased this risk. Age (female or male) and male sexual dysfunction were factors related to lower individual FSFI domain scores.

Read Full Article

J Obstet Gynaecol. 2012 Feb; 32(2): 180-4
Rodríguez MC, Chedraui P, Schwager G, Hidalgo L, Pérez-López FR

The present study aimed at assessing sexuality after hysterectomy using the Female Sexual Function Index (FSFI). A telephone survey was conducted among women 1 year after a hysterectomy for benign cause. The FSFI and a general questionnaire containing personal and partner sociodemographic data were applied. A total of 100 sexually active women participated. Bilateral oophorectomy was performed among 41%. Upon survey, 63% were on hormone therapy (HT) and 2% on psychotropic drugs. Regarding the partner (n = 100), 32% abused alcohol; 11% had erectile dysfunction; 67% premature ejaculation and 11% were unfaithful. Total FSFI score was 19.4 ± 3.6 (median 19.8) and for the domains: 3.2 ± 0.9 (desire); 3.2 ± 0.9 (arousal); 3.1 ± 0.6 (lubrication); 3.1 ± 0.7 (orgasm); 3.5 ± 1.1 (satisfaction) and 3.2 ± 1.2 (pain/dyspareunia). All women displayed sexual dysfunction (total FSFI score ≤ 26.55). A total of 53% presented FSFI scores equal to or below the calculated median for the series. Logistic regression determined that among women who had had a hysterectomy, male premature ejaculation was related to an overall poorer female sexual function (lower total FSFI scorings), whereas sometime oral contraceptive use decreased this risk. Age (female or male) and male sexual dysfunction were factors related to lower individual FSFI domain scores.

Read Full Article