J Sex Med. 2010 Jun 25;
Carson C, Wyllie M

ABSTRACT Introduction. PSD502 is a novel aerosolized, lidocaine-prilocaine, spray being developed for the treatment of lifelong premature ejaculation. The clinical profile of PSD502 is described in one of two double-blind, placebo-controlled, phase III studies. Aim. To determine the effect of PSD502 on the Index of Premature Ejaculation (IPE) and intravaginal ejaculatory latency (IELT) of men with lifelong PE. Methods. Men with lifelong PE who documented an IELT </= 1 minute with two or more of the first three sexual encounters during a 4-week baseline period were randomized to receive double-blind treatment with PSD502 or placebo for 3 months. Patients completed IPE and Premature Ejaculation Profile questionnaires at entry and monthly visits, and recorded stop-watch timed IELT during each encounter. Safety was assessed by collecting adverse event data and standard safety measures. Main Outcome Measures. Stopwatch timed IELT recordings and a patient-reported outcome questionnaire the IPE were used in this study to determine the effect of PSD502 applied topically 5 minutes before intercourse. Results. Two hundred fifty-six men with PE were randomized from 38 centers in the U.S., Canada, and Poland. The geometric mean IELT over the 3-month treatment period increased from a baseline of 0.56 minute and 0.53 minute in the PSD502 and placebo group respectively to 2.60 and 0.80 minute. There were significantly greater increases in the scores for the IPE domains of ejaculatory control, sexual satisfaction and distress in the PSD502 group than in the placebo group, with a mean 5.0 point difference between treatments in change from baseline in the IPE domain for ejaculatory control, 4.6 point difference in change from baseline in the IPE domain for sexual satisfaction, and a 2.5 point difference in change from baseline in the IPE domain for distress. This was supported by improvements in all secondary endpoints. Conclusion. In this study, PSD502 applied topically to the glans penis 5 minutes before intercourse showed significantly improved ejaculatory latency, ejaculatory control, sexual satisfaction and distress and was shown to be well tolerated by patients and partners. Carson C, and Wyllie M. Improved ejaculatory latency, control and sexual satisfaction when PSD502 is applied topically in men with premature ejaculation: Results of a phase III, double-blind, placebo-controlled study. J Sex Med **;**:**-**.

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J Sex Marital Ther. 2010 Jul; 36(4): 303-12
Jern P, Santtila P, Johansson A, Alanko K, Salo B, Sandnabba NK

Potential effects of sexual orientation on ejaculatory function have been overlooked in the literature. In anticipation of the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-V), attempts have been made to formulate universally suitable definitions for different subtypes of premature ejaculation. However, the proposed definitions are centered around intravaginal ejaculation latency time, and little consideration has been given to whether such definitions are applicable to gay or bisexual men. The present study aimed to investigate effects of sexual orientation on premature and delayed ejaculation. When differences in frequencies and patterns of sexual activities were controlled for, there remained no significant effects of sexual orientation on ejaculatory dysfunction.

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BJU Int. 2010 Jun 14;
Wyllie MG, Hellstrom WJ

Study Type – Aetiology (case control) Level of Evidence 3b OBJECTIVES To investigate the correlation between penile hypersensitivity and premature ejaculation (PE), as defined by the criteria identified by the International Society of Sexual Medicine (ISSM). Penile hypersensitivity as a cause of PE is based on historical clinical neurophysiological data and clinical efficacy of the topical desensitizing agent PSD502 in the treatment of PE. PSD502 is a eutectic-like mixture of two local anaesthetics, lidocaine and prilocaine, whose primary action is to reduce neuronal conduction in sensory afferents. METHODS Historical neurophysiological data was reviewed, together with data from the recent PSD502 clinical trials, including the first published double-blind clinical trial data evaluating a topical desensitizing agent in a population of men with PE, as per the new ISSM definition. The clinical profile of PSD502, based on its local anaesthetic properties, is used as a surrogate index of the role of sensory afferents in the ejaculatory reflex. RESULTS The published data does not support unequivocally penile hypersensitivity as the cause of PE. Interpretation of the data is hampered by the variability of the populations described as having PE across studies. Data from the PSD502 clinical trials clearly shows that PSD502 increases ejaculatory latency, and improves control and sexual satisfaction when applied topically to men with PE 5 min before intercourse, enabling subjects to delay ejaculation up to six times longer than those who used a placebo. CONCLUSION The clinical profile of PSD502 lends credibility to the penile hypersensitivity hypothesis for PE. The predominant action of local anaesthetics is to reduce neuronal firing in sensory afferents; the clinical profile of PSD502, which shows improvement of ejaculatory function in the absence of a generalized reduction in penile sensitivity, can most readily be explained based on an underlying hypersensitivity in patients with PE.

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BJU Int. 2010 Jun 14;
Wyllie MG, Hellstrom WJ

Study Type – Aetiology (case control) Level of Evidence 3b OBJECTIVES To investigate the correlation between penile hypersensitivity and premature ejaculation (PE), as defined by the criteria identified by the International Society of Sexual Medicine (ISSM). Penile hypersensitivity as a cause of PE is based on historical clinical neurophysiological data and clinical efficacy of the topical desensitizing agent PSD502 in the treatment of PE. PSD502 is a eutectic-like mixture of two local anaesthetics, lidocaine and prilocaine, whose primary action is to reduce neuronal conduction in sensory afferents. METHODS Historical neurophysiological data was reviewed, together with data from the recent PSD502 clinical trials, including the first published double-blind clinical trial data evaluating a topical desensitizing agent in a population of men with PE, as per the new ISSM definition. The clinical profile of PSD502, based on its local anaesthetic properties, is used as a surrogate index of the role of sensory afferents in the ejaculatory reflex. RESULTS The published data does not support unequivocally penile hypersensitivity as the cause of PE. Interpretation of the data is hampered by the variability of the populations described as having PE across studies. Data from the PSD502 clinical trials clearly shows that PSD502 increases ejaculatory latency, and improves control and sexual satisfaction when applied topically to men with PE 5 min before intercourse, enabling subjects to delay ejaculation up to six times longer than those who used a placebo. CONCLUSION The clinical profile of PSD502 lends credibility to the penile hypersensitivity hypothesis for PE. The predominant action of local anaesthetics is to reduce neuronal firing in sensory afferents; the clinical profile of PSD502, which shows improvement of ejaculatory function in the absence of a generalized reduction in penile sensitivity, can most readily be explained based on an underlying hypersensitivity in patients with PE.

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Expert Opin Pharmacother. 2010 Jul; 11(10): 1741-52
McMahon CG

Importance of the field: Premature ejaculation (PE) is a common male sexual disorder which is associated with substantial personal and interpersonal negative psychological factors. Drug treatment of PE with an off-label antidepressant selective serotonin reuptake inhibitor (SSRI) drug is common. The lack of an approved drug and total reliance on off-label treatment represents a substantial unmet treatment need. Areas covered in this review: Medline and the proceedings of major international and regional scientific meetings during the period 1994 – 2010 were searched for publications or abstracts using the word ‘dapoxetine’ in the title, abstract or keywords. This search was then manually cross-referenced for all papers. This review encompasses studies of dapoxetine pharmacokinetics, animal studies, human phase I, II and III efficacy and safety studies and drug-interaction studies. Dapoxetine is a potent SSRI, which is administered on demand 1 – 3 h before planned sexual contact. Dapoxetine is rapidly absorbed and eliminated, resulting in minimal accumulation and has dose-proportional pharmacokinetics, which are unaffected by multiple dosing. Dapoxetine 30 and 60 mg has been evaluated in five randomized, double-blind, placebo-controlled studies in 6,081 men aged >/= 18 years. Outcome measures included stopwatch-measured intravaginal ejaculatory latency time (IELT), Premature Ejaculation Profile (PEP) items, clinical global impression of change (CGIC) in PE, and adverse events. Mean IELT, all PEP items and CGIC improved significantly with both doses of dapoxetine versus placebo (p < 0.001 for all). The most common adverse events included nausea, dizziness and headache, and evaluation of validated rated scales demonstrated no SSRI class-related effects with dapoxetine use. What the reader will gain: Readers will gain insight into the epidemiology, pathophysiology and contemporary drug treatment of premature ejaculation. Take home message: Dapoxetine, as the first drug developed for PE, is an effective and safe treatment for PE and represents a major advance in sexual medicine.

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Wouldn’t you like to have a larger penis?  Most men honestly wouldlove to possess a penis that was bigger and stronger and kept rock solid erections longer. With the use of best quality male enhancement products, you not only can develop a bigger penis, but as well an erection that is faster to arrive and lasts longer.

Know What Kind of Male Enhancement Product You’re Taking

Also of great importance, you don’t really know what’s in the product you’re taking, even with some of the most popular enhancement products available. If you’re going to take enhancement products, you want to know what they are made of and that they are safe.

One easy way to make a fast judgement about safety is to only buy products made in the USA or EU (European Union). They have the strictest of manufacturing and health standards, and use only recognizably safe ingredients.

The other choice to take is all natural vs synthetic ingredients. Many male enhancement products use natural ingredients that have been used for decades (if not longer!), and have a long track record of safe usage. Sythetic ingredients have to be tested to be proven to be safe, but many do not have such a proven track record of safety.

How Do Male Enhancement Pills Work?

Male enhancement pills work by increasing the hormone levels in the body while stimulating circulation and blood flow in the genital area. By improving circulation and increasing the blood flow to the penis, they actually increase the strength and duration of your erections. They actually give you a healthier penis, which will help to prevent premature ejaculation. A healthy and hard penis always looks larger, too!

Male enhancement pills can add a real boost to your bedroom and sex life. Those days of stress, long working hours, bad diet, and not enough sleep, all play their toll. More and more men are turning to natural male enhancement products not because they have any specific medical issue, but to simply deal with the rush of life.

Male enhancement and aphrodisiac products can offer you harder and longer erections, increased semen production, fewer premature ejaculations and an increase in stamina and sex drive. If you’re going to be using male enhancement pills, be sure choose the ones that offer a guarantee of safety, and with some kind of proven track record – after all, it is your health.

For More Male Enhancement Products and Techniques Advice visit our site: About Male Enhancement

Herbal Ignite is a sexual enhancement item designed to “boost natural virility and market a better sex life and sense of well being in men and women.” This herbal supplement claims to “increase testosterone naturally, restore organic virility and energy, and decrease that tired, stressed out-feeling.”

We’re unclear as to precisely why a woman would wish to “increase testosterone,” or “boost virility.” Although this product claims to become suitable for each males and women, we cannot assist but really feel that its mechanism caters more to male requirements. In addition, we feel that this product’s ingredient list is somewhat incomplete, in spite of the inclusion of the few quality elements. We will review this product for its ability to equally enhance the sexual experience for each genders.

Ingredients at a glance

This formula might contain some with the following elements: Tribulus Terrestris, Avena Sativa and Horny Goat Weed.

Ingredients in Focus

Tribulus Terrestris is known to become a single of the much more efficient sexual enhancement ingredients presently accessible. This herbal component is recognized to normally improve testosterone and improve potency. Whilst both of these outcomes would definitely be of benefit to most men, we wonder how they might be useful to ladies. The ingredient, Avena Sativa, which is the scientific name for oats, isn’t proven as a sexual enhancer at this time, in spite of its historic use for this objective. One expert states, “Avena sativa has been utilized medicinally because the Middle Ages, yet I have not arrive across any reference to any aphrodisiac advantage that has ever been noted or documented in several hundred many years of use.”

We also would have preferred to determine some other, more targeted ingredients which are known to enhance male sexuality, such as Yohimbe, Panax Ginseng and Damiana. We speculate if possibly these ingredients are already excluded because of their male-specific sexual mechanisms. If this may be the situation, we really feel that this product eventually dilutes and compromises its potential by attempting to cater to each genders.

Learn more about Herbal Ignite Review now

ExtaMax is advertised as the male enhancement supplement that offers maximum size, strength and pleasure. The item markets itself like a safe, organic blood circulation stimulator. It’s a formula consist of all natural ingredients that offer few, if any, side results.

Maximum advantages are typically achieved after two to three months of use, even though some results may be experienced almost instantly after getting the product.

What’s ExtaMax?

ExtaMax is definitely an herbal product contain a proprietary blend of male enhancement ingredients. It is particularly designed to enlarge and sensitize the penis for a a lot more satisfying sexual experience. The items tout many advantages, which consist of:

    * Penile enlargement (particular increases aren’t noted)

    * A lot more frequent, longer and harder erections

    * A lot more intense orgasms

    * Improve penile sensitivity

    * A more satisfying sexual encounter for any man and his partner

This solution is comprised of all organic, time-tested materials that are secure for most men. However, the web site does recommend that men consult with their physician before taking any male enhancement supplement, such as ExtaMax.

There are a quantity of efficient elements in this solution for both maximizing blood circulation and promoting a healthier male reproductive system. Yohimbe bark and L-arginine are especially noted for their effect on maximizing blood flow. The main concern with this record may be the length. A solution that is littered with as well numerous elements may affect the potency with the proven substances contained inside.

Cons of ExtaMax

    * As noted above, the item includes a long ingredient record, which might affect the potency of some of the verified elements. Nevertheless, some with the ingredients listed are recognized for their effectiveness and have appeared in numerous male enhancement items.

    * The product website does not provide information about clinical investigation or testing. It’s a great idea to select supplements that provide this information so you can see for yourself just how effective the formula may be.

    * The product requires a number of months to take effect. According towards the item web site, it typically requires two to 3 months to see the desired effect.

    * The “free” trial offer about the item web site actually sets you up on an auto ship program. This signifies you will receive a shipment of ExtaMax each and every 60 days for which you is going to be charged for. Most of these trial provides require a credit card quantity so the company can collect payment automatically from your account. Some make it very difficult for you to cancel the auto ship whenever you choose you don’t want the product any a lot more.

Read full extamax review here

  If you’re a man who suffers premature ejaculation and want to put an end to the condition, then it’s my guess that you’ll be interested in all possible avenues of treatment. One of the too often overlooked methods to helping treat PE is to change the way that you masturbate as a means of rewiring the ejaculatory reflex. Following are some tips on how you can alter your masturbatory technique to help prevent premature ejaculation.

Tip 1 – Never Masturbate Without A Lubricant

What you’re seeking to achieve when using masturbation as a technique to help overcome PE is to make what you are experiencing as close as possible to the act of normal sex. Masturbating without a lubricant (i.e. with a dry hand) will actually increase your penile sensitivity rather than decrease it – so when it actually comes to the point of getting down and dirty with a woman, you’ll find that your penis won’t be able to adjust to the warm and moist environment. Masturbating with a lubricant allows you to more accurately replicate the experience of having intercourse with a woman and get a better idea of where your point of no return is.

Tip 2 – Don’t Rush Masturbation

Men are naturally engineered to get themselves to the point of ejaculation quickly whilst masturbating. But when it comes to using masturbation as a means of boosting sexual endurance then you really do need to take the opposite approach. SLOW is the word and SLOW is the way. If you’re normally someone who rubs it out in less than a minute then some adjustments will need to be made. But here’s the key: stop all stimulation as soon as you feel close to climax.

In the context of boosting your sexual endurance , masturbation needs to be viewed as a training process. Rushing it is the worst thing you can do. Aim to progressively stretch the process  out to 15 to 20 minutes in order to reap real advantages from this technique.

Tip 3 – Don’t Get Distracted

The right time to train yourself to last longer is when you are relaxed, and unlikely to be distracted. If you are in a hurry, then simply don’t do it . Pick another occassion .

Tip 4 – Don’t Get Too Excited

A lot of men use this technique incorrectly . You’ll find that they will watch pornography until they start getting aroused and it is at this point that they start stimulating themselves. This is the wrong way to go about it. You should be looking to build your arousal from the very beginning as it is only by doing this that you will understand when and how to control your arousal, which is the key component in helping you have longer lasting sex without ejaculating too early.

When used correctly, masturbation can be a very effective aid in helping you increase your sexual endurance. By keeping these 4 tips in mind, you will be well on your way to permanently preventing premature ejaculation.

Although there are many contributing factors why relationships go through a breakup, when it came to men the top reason seems to be sex, according to a five year study called The Couples Project. 

Why is the occurrence of a cheating man so prevalent?

Why do 65% of marriages not last?

Why do the majority of relationships never make it to the marriage stage?

The study included over 500 men and focused on men and sex in committed relationships.  The objective was not to influence behavior, such as counseling does but instead to learn what was the motivation for the behavior men were displaying that was causing them in many instances to be cheating men.

The study covered topics such as

What attracts you and how important is it to you? 

Is it important enough to cause you to become a cheating man? 

Does your partner really know your sexual needs? 

Do you feel you can honestly discuss the topic of sex in detail with your partner?

And most important, the study included open ended questions such as; what is the reference point you wish your partner had concerning men and sex that would allow you to truly connect on this subject.  In other words, what do you wish your partner already understood concerning sex?

Some of the findings were surprising

   89% of men felt their partner did not really know them when it came to sexuality. 

   When a man initiated a break up, he usually disguised the reason into something else if it had to do with sex. 

Imagine it. 

Men terminate relationships because they felt their needs weren’t met, AND they felt they cannot even honestly discuss the topic with their partner AND they disguised the reason for the breakup, probably leaving their partner confused.

And worse, this cycle seems to be learned and repeated over and over.

The study also evaluated the accuracy of some broadly held beliefs including

The concept of a female needing the perfect body to keep a man attracted.

Or, if she does not have that ever elusive perfect body, she needs to vigilantly watch and keep her man’s options closed so he won’t wander.   

Surprisingly, the Couples Project concluded that from a man’s point of view, both of these assumptions were false.   

More information on: What Men Wont Tell Women About Sex- Men Sexuality and Relationships can be viewed at www.CouplesProject.org.